Linked Life Data

6581982

Source:http://linkedlifedata.com/resource/pubmed/id/6581982

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-3-8
pubmed:abstractText
There are subgroups of subjects showing increased bronchial responsiveness to histamine among patients with sarcoidosis and with allergic alveolitis (farmer's lung). In these subjects the airway reactivity is comparable with that usually encountered in patients with asthma and in many cases of bronchitis. In many of our patients with hyperreactive sarcoidosis and alveolitis, the increased reactivity was transient, lasting for one to two months during the acute stage of the disease. By electron microscopy we have shown that some of these patients have extensive epithelial damage which could increase epithelial permeability and uncover superficial afferent nerve endings. Indeed, superficial epithelial afferent nerves were found, and it is possible that irritation of these nerve endings causes enhanced bronchoconstriction via the vagal reflex. The transient nature of the hyperreactivity observed in patients with sarcoidosis and alveolitis may indicate that the epithelial changes are readily reversible. The recovery of the epithelium could perhaps be demonstrated by taking serial bronchial biopsies during the course of the disease. Because the electron microscopic specimens represented only a small area of bronchial epithelium, it is difficult to draw any conclusions as to a quantitative relationship between the amount of total epithelial damage and the degree of bronchial reactivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0106-4347
pubmed:author
pubmed:issnType
Print
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
267-84
pubmed:dateRevised
2008-2-21
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Non-specific bronchial reactivity and ultrastructure of the airway epithelium in patients with sarcoidosis and allergic alveolitis.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't