Linked Life Data

6576192

Source:http://linkedlifedata.com/resource/pubmed/id/6576192

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-9-23
pubmed:abstractText
The possible effects of dietary protein on pancreatic cancer induced in outbred Syrian golden hamsters by N-nitrosobis(2-oxopropyl)amine (BOP) were studied. Three levels of casein as protein at low [LP = 9 g/385 kilocalories (kcal)], medium (MP = 18 g/385 kcal), or high levels (HP = 36 g/385 kcal) were fed in two sequences to 4 groups of hamsters. The effects of protein level on the initiation phase of BOP carcinogenesis were examined in hamsters fed LP or HP from 3 through 7 weeks of age, followed by MP for the remainder of their lives. The role of protein level on the promotional (developmental) phase of carcinogenesis was evaluated in hamsters fed (from 3 through 7 wk of age) MP, followed by LP or HP for the rest of their lives. One-half of the hamsters from each of the 4 groups received a single sc BOP injection (10 mg/kg body wt) at 8 weeks of age. Changes in diet from one type to the other occurred 2 days after BOP treatment. An MP diet fed before and after BOP served as the experimental control diet. The results demonstrated that the LP diet inhibited the developmental phase of carcinogenesis only in females, whereas the MP and HP diets did not affect initiation or promotion of cancer in either sex. The inhibitory effect of the LP diet in pancreatic carcinogenicity only in females calls for further studies.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
347-53
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Modifying factors in pancreatic carcinogenesis in the hamster model. IV. Effects of dietary protein.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.