| pubmed-article:6574453 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6574453 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:6574453 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:6574453 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:6574453 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:6574453 | lifeskim:mentions | umls-concept:C0007004 | lld:lifeskim |
| pubmed-article:6574453 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:6574453 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:6574453 | lifeskim:mentions | umls-concept:C1157363 | lld:lifeskim |
| pubmed-article:6574453 | lifeskim:mentions | umls-concept:C0439836 | lld:lifeskim |
| pubmed-article:6574453 | lifeskim:mentions | umls-concept:C1705294 | lld:lifeskim |
| pubmed-article:6574453 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:6574453 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:6574453 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:6574453 | pubmed:dateCreated | 1983-7-8 | lld:pubmed |
| pubmed-article:6574453 | pubmed:abstractText | Cell surface carbohydrate antigens and their metabolism were investigated during the course of differentiation of murine cultured leukemia cells (M1) into macrophage-like cells. The major glycolipids in undifferentiated M1 cells were of the ganglio series, with a small amount of lacto-series glycolipids. A novel branched structure was found as a tetraosylceramide of M1- cells. Upon differentiation, synthesis of lacto-series glycolipids was significantly enhanced and synthesis of globo-series glycolipids was newly induced but the ganglio-series synthesis was much reduced. Undifferentiated cells expressed only i antigen (i+I-Pk-); differentiated macrophage-like cells became I-antigen dominant and Pk-antigen positive (i+/-I+Pk+). The changes proceeded in two sequential steps: (i) an enhancement of lacto-series glycolipid synthesis associated with the conversion of i antigen to I antigen, and (ii) subsequent induction of globo-series glycolipid synthesis accompanied by the appearance of Pk antigen. The experimental system offers a clue for studies on the process of branching (i-to-I conversion) as well as the biological significance of three major glycolipids (globo-, lacto-, and ganglio-series) as markers of cell differentiation. | lld:pubmed |
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| pubmed-article:6574453 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6574453 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6574453 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6574453 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6574453 | pubmed:month | May | lld:pubmed |
| pubmed-article:6574453 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6574453 | pubmed:author | pubmed-author:HakomoriSS | lld:pubmed |
| pubmed-article:6574453 | pubmed:author | pubmed-author:KannagiRR | lld:pubmed |
| pubmed-article:6574453 | pubmed:author | pubmed-author:LeveryS BSB | lld:pubmed |
| pubmed-article:6574453 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6574453 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:6574453 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6574453 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6574453 | pubmed:pagination | 2844-8 | lld:pubmed |
| pubmed-article:6574453 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6574453 | pubmed:meshHeading | pubmed-meshheading:6574453-... | lld:pubmed |
| pubmed-article:6574453 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6574453 | pubmed:articleTitle | Sequential change of carbohydrate antigen associated with differentiation of murine leukemia cells: i-I antigenic conversion and shifting of glycolipid synthesis. | lld:pubmed |
| pubmed-article:6574453 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6574453 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6574453 | lld:pubmed |
