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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0007004,
umls-concept:C0007589,
umls-concept:C0007634,
umls-concept:C0023418,
umls-concept:C0332281,
umls-concept:C0392747,
umls-concept:C0439836,
umls-concept:C0591833,
umls-concept:C1157363,
umls-concept:C1511938,
umls-concept:C1705294
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pubmed:issue |
10
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pubmed:dateCreated |
1983-7-8
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pubmed:abstractText |
Cell surface carbohydrate antigens and their metabolism were investigated during the course of differentiation of murine cultured leukemia cells (M1) into macrophage-like cells. The major glycolipids in undifferentiated M1 cells were of the ganglio series, with a small amount of lacto-series glycolipids. A novel branched structure was found as a tetraosylceramide of M1- cells. Upon differentiation, synthesis of lacto-series glycolipids was significantly enhanced and synthesis of globo-series glycolipids was newly induced but the ganglio-series synthesis was much reduced. Undifferentiated cells expressed only i antigen (i+I-Pk-); differentiated macrophage-like cells became I-antigen dominant and Pk-antigen positive (i+/-I+Pk+). The changes proceeded in two sequential steps: (i) an enhancement of lacto-series glycolipid synthesis associated with the conversion of i antigen to I antigen, and (ii) subsequent induction of globo-series glycolipid synthesis accompanied by the appearance of Pk antigen. The experimental system offers a clue for studies on the process of branching (i-to-I conversion) as well as the biological significance of three major glycolipids (globo-, lacto-, and ganglio-series) as markers of cell differentiation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-1067617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-107170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-13767181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-271144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-281705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-307692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-351328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-4187945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-4588107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-512581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-5500973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-568034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-6124244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-6129244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-6268725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-67165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-6774338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-6945185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-6950153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-7004456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-7023369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-7033147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-7045228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-7115742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-7224165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-7287743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-7358986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-7470108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6574453-78708
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2844-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6574453-Animals,
pubmed-meshheading:6574453-Carbohydrate Sequence,
pubmed-meshheading:6574453-Cell Differentiation,
pubmed-meshheading:6574453-Cell Line,
pubmed-meshheading:6574453-Gangliosides,
pubmed-meshheading:6574453-Glycolipids,
pubmed-meshheading:6574453-I Blood-Group System,
pubmed-meshheading:6574453-Leukemia, Experimental,
pubmed-meshheading:6574453-Macrophages,
pubmed-meshheading:6574453-Mice,
pubmed-meshheading:6574453-P Blood-Group System
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pubmed:year |
1983
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pubmed:articleTitle |
Sequential change of carbohydrate antigen associated with differentiation of murine leukemia cells: i-I antigenic conversion and shifting of glycolipid synthesis.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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