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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1983-6-10
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pubmed:abstractText |
Streptomyces glaucescens strain GLAO (=ETH 22794) produces hydroxystreptomycin and has a high natural resistance to hydroxystreptomycin, dihydrostreptomycin and streptomycin. The wild-type strain gives rise spontaneously to streptomycin-sensitive (StrS-) variants at a frequency of 0 . 2 to 1 . 4%. These mutants lack streptomycin phosphotransferase activity responsible for the wild-type resistance to streptomycin group antibiotics and are unable to produce detectable amounts of hydroxystreptomycin. Mapping experiments showed that the strS marker lies between the chromosomal markers lys-2 and ura-3 on the linkage map of S. glaucescens. The molecular basis for instability of this marker is as yet unknown.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1287
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
519-27
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:6573433-Alleles,
pubmed-meshheading:6573433-Chromosome Mapping,
pubmed-meshheading:6573433-Chromosomes, Bacterial,
pubmed-meshheading:6573433-Crosses, Genetic,
pubmed-meshheading:6573433-Drug Resistance, Microbial,
pubmed-meshheading:6573433-Genetic Linkage,
pubmed-meshheading:6573433-Genetic Markers,
pubmed-meshheading:6573433-Mutation,
pubmed-meshheading:6573433-Streptomyces,
pubmed-meshheading:6573433-Streptomycin
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pubmed:year |
1983
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pubmed:articleTitle |
Chromosomal instability in Streptomyces glaucescens: mapping of streptomycin-sensitive mutants.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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