Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1983-5-27
pubmed:abstractText
Previous work has shown that the light chain of protein C, an anticoagulant plasma protein, contains an unusual amino acid [Fernlund, P. & Stenflo, J. (1982) J. Biol. Chem. 257, 12170-12179]. To determine the structure of this amino acid a heptapeptide, CMCys-Ile-X-Gly-Leu-Gly-Gly (residues 69-75 in the light chain), was isolated from enzymatic digests of the light chain. According to automatic Edman sequence analysis, 1H NMR spectroscopy, and mass spectrometry the heptapeptide had beta-hydroxyaspartic acid in its third position, which corresponds to position 71 in the light chain of protein C. Analysis of acid and aminopeptidase M hydrolysates of the heptapeptide showed the beta-hydroxyaspartic acid to be the erythro form. Acid hydrolysis of protein C released approximately equal to 1 mol of beta-hydroxyaspartic acid per mol of protein. The function of this amino acid, which, to the best of our knowledge, has not been found previously in proteins, is unknown.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-1245477, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-1270437, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-128988, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-13753215, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-13765990, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-14342490, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-291916, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-468991, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-4699560, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-474958, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-508770, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-588557, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-5968723, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-6287289, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-656560, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-6894592, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-6895379, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-6896876, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-694842, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-7016211, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-7017729, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-7356933, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-936101, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-942379, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-975566, http://linkedlifedata.com/resource/pubmed/commentcorrection/6572939-990250
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1802-6
pubmed:dateRevised
2010-9-10
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
beta-Hydroxyaspartic acid in vitamin K-dependent protein C.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't