pubmed-article:6572362 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:6572362 | lifeskim:mentions | umls-concept:C0042153 | lld:lifeskim |
pubmed-article:6572362 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
pubmed-article:6572362 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
pubmed-article:6572362 | lifeskim:mentions | umls-concept:C1157234 | lld:lifeskim |
pubmed-article:6572362 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
pubmed-article:6572362 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
pubmed-article:6572362 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:6572362 | pubmed:dateCreated | 1983-4-15 | lld:pubmed |
pubmed-article:6572362 | pubmed:abstractText | Administration of gamma-glutamylcystine or of gamma-glutamylcysteine disulfide to mice leads to significantly increased levels of glutathione in the kidney as compared to controls given glutamate plus cysteine (or cystinylbisglycine). Studies with gamma-glutamylcystine selectively labeled with 35S in either the internal or external S atom indicate preferential utilization of the gamma-glutamylcysteine moiety of this compound for glutathione synthesis. Mice depleted of glutathione by treatment with buthionine sulfoximine do not significantly use the disulfides gamma-glutamylcystine or gamma-glutamylcysteine disulfide but do use gamma-glutamylcysteine for glutathione synthesis. These findings suggest a pathway in which gamma-glutamylcystine, formed by transpeptidation between glutathione and cystine, is transported and reduced by transhydrogenation with glutathione to cysteine and gamma-glutamylcysteine; the latter is used directly for glutathione synthesis. The findings show transport of gamma-glutamyl amino acids, indicate an alternative pathway of glutathione synthesis, and demonstrate a means of increasing kidney glutathione levels. | lld:pubmed |
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pubmed-article:6572362 | pubmed:language | eng | lld:pubmed |
pubmed-article:6572362 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6572362 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:6572362 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:6572362 | pubmed:month | Feb | lld:pubmed |
pubmed-article:6572362 | pubmed:issn | 0027-8424 | lld:pubmed |
pubmed-article:6572362 | pubmed:author | pubmed-author:MeisterAA | lld:pubmed |
pubmed-article:6572362 | pubmed:author | pubmed-author:AndersonM EME | lld:pubmed |
pubmed-article:6572362 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:6572362 | pubmed:volume | 80 | lld:pubmed |
pubmed-article:6572362 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:6572362 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:6572362 | pubmed:pagination | 707-11 | lld:pubmed |
pubmed-article:6572362 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:6572362 | pubmed:year | 1983 | lld:pubmed |
pubmed-article:6572362 | pubmed:articleTitle | Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis. | lld:pubmed |
pubmed-article:6572362 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:6572362 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:6572362 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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