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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-4-15
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pubmed:abstractText |
Administration of gamma-glutamylcystine or of gamma-glutamylcysteine disulfide to mice leads to significantly increased levels of glutathione in the kidney as compared to controls given glutamate plus cysteine (or cystinylbisglycine). Studies with gamma-glutamylcystine selectively labeled with 35S in either the internal or external S atom indicate preferential utilization of the gamma-glutamylcysteine moiety of this compound for glutathione synthesis. Mice depleted of glutathione by treatment with buthionine sulfoximine do not significantly use the disulfides gamma-glutamylcystine or gamma-glutamylcysteine disulfide but do use gamma-glutamylcysteine for glutathione synthesis. These findings suggest a pathway in which gamma-glutamylcystine, formed by transpeptidation between glutathione and cystine, is transported and reduced by transhydrogenation with glutathione to cysteine and gamma-glutamylcysteine; the latter is used directly for glutathione synthesis. The findings show transport of gamma-glutamyl amino acids, indicate an alternative pathway of glutathione synthesis, and demonstrate a means of increasing kidney glutathione levels.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-1112810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-14313364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-237267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-237905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-28177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-33187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-34150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-38242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-42902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-42913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-4388022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-6051513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-6106190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-6110666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-6114489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-6262375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-6950392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-7304929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-7416462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-9080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6572362-984420
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
707-11
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1983
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pubmed:articleTitle |
Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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