Linked Life Data

6570669

Source:http://linkedlifedata.com/resource/pubmed/id/6570669

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10-11
pubmed:dateCreated
1985-6-20
pubmed:abstractText
We studied whether the components of the kallikrein-kinin system are present in the central nervous system. We found that human cerebrospinal fluid (CSF) contains free kinins: 53 +/- 15 pg/ml; kininogen: 10.9 +/- 2.1 ng kinin equivalent/ml, and kininogenase activity: 5.0 +/- 2.1 ng kinins/ml/minute. Kininogenase activity was 2-3 fold augmented by preincubation with trypsin. Soybean trypsin inhibitor completely inhibited untreated CSF and partially inhibited trypsin activated kininogenase. Kininogenase activity and immunoreactive glandular kallikrein were present in rat brain, and their concentrations in hypothalamus is several-fold higher than in cortex, pons-medulla, basal ganglia and cerebellum. In the hypophysis, activity in pars-intermedia was between 6- and 20-fold higher than in posterior and anterior hypophysis, respectively. High activity was also found in the pineal gland. The kallikrein-kinin system is present in the central nervous system where it may participate in modulation of nervous and neuroendocrine functions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0730-0077
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1731-8
pubmed:dateRevised
2008-2-12
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Kallikrein-kinins in the central nervous system.
pubmed:publicationType
Journal Article, Comparative Study