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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
3
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pubmed:dateCreated |
1983-11-23
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pubmed:abstractText |
The toxic agent purothionin was conjugated to the monoclonal antibody 225.28S to a human high-molecular-weight melanoma-accociated antigen. The toxic conjugate displayed in vitro toxicity to cultured human Colo 38 melanoma cells as indicated by reduced uptake of 3H-thymidine following a 24-h incubation and loss of cell viability following a 7-day incubation. The effect is dose-dependent and is specific since addition of the toxic conjugate to a cultured Raji B lymphoid cells did not affect their 3H-thymidine uptake or their viability.
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pubmed:grant |
|
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
0340-7004
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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|
pubmed:pagination |
206-9
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|
pubmed:dateRevised |
2007-11-14
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|
pubmed:meshHeading |
pubmed-meshheading:6555062-Antibodies, Monoclonal,
pubmed-meshheading:6555062-Antimicrobial Cationic Peptides,
pubmed-meshheading:6555062-Cell Survival,
pubmed-meshheading:6555062-Cells, Cultured,
pubmed-meshheading:6555062-DNA,
pubmed-meshheading:6555062-Humans,
pubmed-meshheading:6555062-Melanoma,
pubmed-meshheading:6555062-Molecular Weight,
pubmed-meshheading:6555062-Plant Proteins,
pubmed-meshheading:6555062-Staphylococcal Protein A
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|
pubmed:year |
1983
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|
pubmed:articleTitle |
Selective in vitro toxicity of purothionin conjugated to the monoclonal antibody 225.28S to a human high-molecular-weight melanoma-associated antigen.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
