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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1984-7-13
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pubmed:abstractText |
The mRNAs for different variant surface antigens of Trypanosoma brucei start with the same 35 nucleotides. This sequence is encoded by a separate mini-exon, located in a 1.35-kb repetitive element. We have reported that trypanosomes contain many transcripts that hybridize to mini-exon probes, even if they do not make the surface antigens. We show here that these transcripts have the mini-exon sequence at their 5' end; they do not contain other sequences from the mini-exon repeat element and are polyadenylated. We have cloned DNA complementary to trypanosome mRNAs and randomly selected 17 clones containing mini-exon sequences. Thirteen of these are derived from different genes that do not code for surface antigens. We conclude that the mini-exon sequence is a common element at the 5' end of many trypanosome mRNAs. As the 200 genes for mini-exons are highly clustered, linkage of the mini-exon sequence to the remainder of most mRNAs may require discontinuous transcription.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-10605439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-17737996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-388356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6101223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6159641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6176879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6177038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6196191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6265900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6283379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6287414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6292859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6300689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6304645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6306248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6306255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6313212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6313213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6317186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6319121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-661969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-67961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-6942953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-704349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-7121578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-7121582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-7166234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-7254319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-7364218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6547230-881736
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3777-90
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:6547230-Amino Acid Sequence,
pubmed-meshheading:6547230-Animals,
pubmed-meshheading:6547230-Base Composition,
pubmed-meshheading:6547230-Base Sequence,
pubmed-meshheading:6547230-Cloning, Molecular,
pubmed-meshheading:6547230-DNA,
pubmed-meshheading:6547230-Genes,
pubmed-meshheading:6547230-Glycoproteins,
pubmed-meshheading:6547230-Nucleic Acid Hybridization,
pubmed-meshheading:6547230-RNA, Messenger,
pubmed-meshheading:6547230-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:6547230-Transcription, Genetic,
pubmed-meshheading:6547230-Trypanosoma brucei brucei,
pubmed-meshheading:6547230-Variant Surface Glycoproteins, Trypanosoma
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pubmed:year |
1984
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pubmed:articleTitle |
Many trypanosome messenger RNAs share a common 5' terminal sequence.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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