Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1984-2-20
|
| pubmed:abstractText |
Thirty children and adolescents with rhabdomyosarcoma (RMS) entered on IRS-1 in a 5-year period had bone marrow metastases (BMM) at diagnosis. BMM at diagnosis occurred in 30/103 patients (29%) with Clinical Group IV RMS. On the average, patients with BMM were older with more extremity primaries than other IRS-1 patients. Alveolar histology was present in 15/30 patients (50%) with BMM, compared to 19% on IRS-1. Eleven patients received vincristine, dactinomycin, cyclophosphamide (VAC), while 19 patients received VAC with Adriamycin (ADR). The overall complete response (CR) rate was 60%. The median disease-free survival times by treatment were 17 weeks with VAC and 32 weeks for VAC + ADR (P greater than 0.10). Relapse from CR in Clinical Group IV patients with BMM occurred in 16/18 patients (89%) and was significantly higher than in 17/29 Clinical Group IV patients (59%) without BMM (P less than 0.035). BMM at diagnosis in children and adolescents with RMS is frequently associated with alveolar histology and is a poor prognostic sign.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0008-543X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
368-73
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6546301-Adolescent,
pubmed-meshheading:6546301-Adult,
pubmed-meshheading:6546301-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:6546301-Bone Marrow Diseases,
pubmed-meshheading:6546301-Bone Neoplasms,
pubmed-meshheading:6546301-Child,
pubmed-meshheading:6546301-Child, Preschool,
pubmed-meshheading:6546301-Cyclophosphamide,
pubmed-meshheading:6546301-Dactinomycin,
pubmed-meshheading:6546301-Doxorubicin,
pubmed-meshheading:6546301-Extremities,
pubmed-meshheading:6546301-Female,
pubmed-meshheading:6546301-Humans,
pubmed-meshheading:6546301-Infant,
pubmed-meshheading:6546301-Male,
pubmed-meshheading:6546301-Prognosis,
pubmed-meshheading:6546301-Registries,
pubmed-meshheading:6546301-Rhabdomyosarcoma,
pubmed-meshheading:6546301-Time Factors,
pubmed-meshheading:6546301-Vincristine
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Bone marrow metastases at diagnosis in children and adolescents with rhabdomyosarcoma. A report from the intergroup rhabdomyosarcoma study.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|