Linked Life Data

654311

Source:http://linkedlifedata.com/resource/pubmed/id/654311

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1978-7-15
pubmed:abstractText
1. The cestode Moniezia expansa and the nematode Ascaris suum both possess enzymes catalysing the conjugation of glutathione (GSH) with 1-chloro-2,4-dinitrobenzene. 2. The GSH-S-aryl transferase (GSH-S-transferase A) was present in the cytosol of the cestode proglottids and of the nematode intestinal epithelial cells. Other tissues did not contain measurable activity. The enzymes from both species had mol. wt. of about 37 000 and broad pH optima around pH 8.3. Both enzymes were inhibited by Cu2+, Fe3+ and Hg2+ at 1 mM and stimulated by Co2+. 3. Neither M. expansa nor A. suum possessed measurable DDT dehydrochlorinase activity. GSH-S-epoxide transferase (GSH-S-transferase E) activity was indicated in both species; neither species effected the conjugation of bromo- or chlorobenzene. 4. Halogenated anthelmintics were not metabolized to GSH conjugates in the helminths studied and did not inhibit GSH-S-aryltransferase activity towards chlorodinitrobenzene.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0049-8254
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
171-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Glutathione conjugation of some xenobiotics by Ascaris suum and Moniezia expansa.
pubmed:publicationType
Journal Article