Linked Life Data

6541274

Source:http://linkedlifedata.com/resource/pubmed/id/6541274

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-11-9
pubmed:abstractText
To determine the effects of nicotine alkaloids on the microcirculation of a variety of tissues, we infused equimolar concentrations (10(-4)-10(-1) M) of 1-nicotine (N), nor-nicotine (NN), dihydro-metanicotine (DHN) in the skeletal muscle, in a skin flap chamber, and in a saline-perfused mesentery preparation of the rat (WistHan). The qualitative and quantitative responses to these equimolar concentrations were measured by modern microcirculatory techniques. Our data showed that 1-nicotine and its alkaloids differ significantly in dose-dependency, maximal vasoactivity, tissue specificity, and microvascular localization. In conclusion, the small differences in the chemical structure of the pyridine ring which distinguishes the alkaloids cause significantly different microvascular effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0023-2173
pubmed:author
pubmed:issnType
Print
pubmed:volume
62 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
92-100
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Microcirculatory effects of nicotine and related alkaloids.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't