rdf:type |
|
lifeskim:mentions |
umls-concept:C0013227,
umls-concept:C0031327,
umls-concept:C0036208,
umls-concept:C0069567,
umls-concept:C0243102,
umls-concept:C0596235,
umls-concept:C1446409,
umls-concept:C1519628,
umls-concept:C1523867,
umls-concept:C1524059,
umls-concept:C2603343
|
pubmed:issue |
3A
|
pubmed:dateCreated |
1984-7-27
|
pubmed:abstractText |
3,4-Dihydro-6-[4-(3,4- dimethoxybenzoyl )-piperazinyl]-2(1H)- quin olinone ( OPC -8212) is a new positive inotropic agent. In studies designed to elucidate information concerning its mechanism of action, its effect on Ca+ transport and related enzyme activities in sarcolemma, sarcoplasmic reticulum and mitochondria were studied. OPC -8212 was found to have little or no effect on these processes. The mechanism of action therefore is clearly different from other known positive inotropic drugs.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0004-4172
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
34
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
384-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:6540093-Animals,
pubmed-meshheading:6540093-Biological Transport,
pubmed-meshheading:6540093-Calcium,
pubmed-meshheading:6540093-Cardiotonic Agents,
pubmed-meshheading:6540093-Heart,
pubmed-meshheading:6540093-Mitochondria, Heart,
pubmed-meshheading:6540093-Myocardium,
pubmed-meshheading:6540093-Oxygen Consumption,
pubmed-meshheading:6540093-Potassium,
pubmed-meshheading:6540093-Quinolines,
pubmed-meshheading:6540093-Rabbits,
pubmed-meshheading:6540093-Rats,
pubmed-meshheading:6540093-Sarcolemma,
pubmed-meshheading:6540093-Sarcoplasmic Reticulum
|
pubmed:year |
1984
|
pubmed:articleTitle |
Studies on the mechanism of action of 3, 4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-qu inolinone (OPC-8212), a new positive inotropic drug. Enzyme activities and Ca2+ transport processes of sarcolemma and intracellular organelles.
|
pubmed:publicationType |
Journal Article,
In Vitro
|