Linked Life Data

6539707

Source:http://linkedlifedata.com/resource/pubmed/id/6539707

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1984-8-17
pubmed:abstractText
Administration of pertussis toxin (60 micrograms/kg i.p.) to guinea-pigs blocked the ability of morphine, norepinephrine and clonidine to inhibit electrically stimulated contractions in the isolated ileum. The toxin reached its maximum effect 6 days after its administration. The effect of the toxin was reversible; a slow but full recovery of the response to morphine was observed in ilea from guinea-pigs treated with toxin 18 days before the experiment. It is suggested, based on the known action of pertussis toxin, that inhibition of adenylate cyclase through Ni (guanine-nucleotide regulatory protein) is involved in the acute action of morphine, norepinephrine and clonidine in the motoneurons of the myenteric plexus of the ileum.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
377-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Pertussis toxin blocks the action of morphine, norepinephrine and clonidine on isolated guinea-pig ileum.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't