Linked Life Data

6538941

Source:http://linkedlifedata.com/resource/pubmed/id/6538941

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-6-14
pubmed:abstractText
Leucine-enkephalin (LE) at 10(-8) M reduces the maximum chronotropic response of isolated spontaneously beating rat atria to exogenously added (-)-norepinephrine (NE) by approximately 27%, with no effect on the NE ED50 (1.5 X 10(-7) M) for positive chronotropy. This modulatory effect of LE is completely blocked by addition of 10(-7) M naloxone, and seems to be catecholamine-receptor specific, since the positive chronotropic response to forskolin is unaltered in the presence of LE. Isoproterenol (ISO)-induced positive chronotropy is also attenuated by LE. This effect is markedly dependent on the extracellular calcium concentration: LE actually causes a greater than two-fold enhancement of the positive chronotropic effect of ISO at low (0.5 mM) extracellular calcium concentration. A possible role for enkephalins to modulate catecholamine action on the heart via an alteration of catecholamine-induced inward calcium flux is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0143-4179
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Leucine-enkephalin modulation of catecholamine positive chronotropy in rat atria is receptor-specific and calcium-dependent.
pubmed:publicationType
Journal Article