Linked Life Data

6537873

Source:http://linkedlifedata.com/resource/pubmed/id/6537873

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-2-14
pubmed:abstractText
To investigate possible human growth hormone (HGH) bioinactivity, serum radioreceptor assay (RRA) and radioimmunoassay (RIA) comparisons were made in 48 children undergoing an evaluation for growth retardation. Discrepancies between serum HGH concentrations by RRA and RIA were uncommon; the overall RRA/RIA ratio was 0.75. Significantly reduced HGH RRA/RIA ratios were seen at peak time periods following levodopa and arginine hydrochloride stimulation. Two subjects who demonstrated a discrepancy between serum HGH concentrations by RRA and RIA and somatomedin C levels in the hypopituitary range had malnutrition and chronic disease. There appeared to be an inverse correlation between nutrition, as assessed by a height age-weight age ratio, and RRA/RIA ratios in all subjects. While a reduced RRA/RIA ratio supports the diagnosis of bioinactive HGH, the administration of certain HGH secretagogues, malnutrition, and chronic disease may result in low HGH RRA/RIA ratios.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-922X
pubmed:author
pubmed:issnType
Print
pubmed:volume
138
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Growth hormone assessment by radioreceptor and radioimmunoassay. Radioreceptor assay and radioimmunoassay comparisons.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't