Linked Life Data

6537042

Source:http://linkedlifedata.com/resource/pubmed/id/6537042

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1985-9-11
pubmed:abstractText
The radiosensitizing effect of misonidazole after hyperthermia was investigated in C3H mammary carcinoma. The tumors transplanted into the flanks of the mice were heated in a 42.3 degrees C water bath for 30 min. When misonidazole was administrated before heating, the subsequent radiation effect was prominently enhanced, whereas post-heating administration of misonidazole did not enhance the radiation effect significantly. The effect of varying the time between heating and radiation with or without misonidazole was as follows. Without misonidazole, the radiation effect was decreased at 6 hours after heating but increased at 12 hours, then it returned to the initial level at 24 hours and remained until 96 hours after heating. With misonidazole administered 30 min before irradiation, the radiosensitizing effect was observed at 24, 48 and 96 hours after heating. However, the total effects of this procedure were almost the same as the results in the combination without heating. Changes in the hypoxic fraction after hyperthermia are also discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0385-0005
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
The effect of hypoxic radiosensitizer after mild hyperthermia in C3H mammary carcinoma.
pubmed:publicationType
Journal Article