Linked Life Data

6531523

Source:http://linkedlifedata.com/resource/pubmed/id/6531523

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1985-5-1
pubmed:abstractText
A commercial perfluoroether liquid, Fomblin-H Fluorinated Fluid, which is transparent and viscous, was investigated as a possible long-term vitreous substitute. The material belongs to a family of perfluorocarbon derivatives that are generally inert and nontoxic. A space for the vitreous substitute was created in rabbit eyes by a vitreous compression technique using perfluoropropane gas. Fomblin caused gliosis of the retina at 1 month after intravitreous injection. Preretinal membrane formation and retinal disorganization and detachment occurred in two of four eyes enucleated at 3 months, and in all five eyes enucleated at 4 or 6 months. Vacuoles presumably filled with Fomblin were localized histopathologically within the retina. In control eyes injected with medical-grade silicone oil, abnormalities were limited to moderate edema of the nerve fiber and ganglion cell layer. Fomblin was not as well-tolerated by the rabbit retina as was medical-grade silicone oil. Fomblin is not a suitable vitreous substitute.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0275-004X
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
264-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Perfluoroether liquid as a long-term vitreous substitute. An experimental study.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.