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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4-6
|
pubmed:dateCreated |
1985-5-17
|
pubmed:abstractText |
Groups of male Sprague-Dawley rats were injected once daily with phenelzine (15 mg/kg) or tranylcypromine (10 mg/kg) and killed 6 h after drug administration on days 1, 2, 8 and 19. Brains were analyzed for MAO activity by a radiochemical procedure and for 5-HT concentrations by an electron-capture gas chromatographic procedure. Both drugs affected 5-HT concentrations in a similar manner--a significant increase of 5-HT over control levels by day 1, with levels still increasing between days 8 and 19, having attained concentrations approximately 5 times control values by day 19.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0278-5846
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
8
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
653-6
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pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:6531436-Animals,
pubmed-meshheading:6531436-Brain Chemistry,
pubmed-meshheading:6531436-Male,
pubmed-meshheading:6531436-Monoamine Oxidase Inhibitors,
pubmed-meshheading:6531436-Phenelzine,
pubmed-meshheading:6531436-Rats,
pubmed-meshheading:6531436-Rats, Inbred Strains,
pubmed-meshheading:6531436-Serotonin,
pubmed-meshheading:6531436-Tranylcypromine
|
pubmed:year |
1984
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pubmed:articleTitle |
Rat brain concentrations of 5-hydroxytryptamine following acute and chronic administration of MAO-inhibiting antidepressants.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|