Linked Life Data

6529576

Source:http://linkedlifedata.com/resource/pubmed/id/6529576

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
26
pubmed:dateCreated
1985-4-29
pubmed:abstractText
The free energy transfer of several N-acetyl(glycine)n ethyl esters (n = 1-3) and side chain derivatives (Ala, Val, Nva, Leu, Nle, and Phe) from water to urea and guanidine hydrochloride solutions has been determined from the solubility and distribution coefficients of these compounds between aqueous and nonaqueous phases. These uncharged model peptides, unlike the amino acids used for a similar study, avoid complication due to charge effects for the transfer process. The compounds with an increase in the number of glycyl groups show additivity of the group free energy toward the transfer from water to urea solution but not to guanidine hydrochloride solution. The derivatives with a side chain show that the principle of group additivity does not hold true for the aliphatic side chains for the transfer to either urea or guanidine hydrochloride solutions. In fact, the free energy of transfer of the side chains, viz., aliphatic ones, is found to be energetically unfavorable in moderately high denaturant concentration. Phenylalanyl, the only aromatic side chain studied here, showed a favorable free energy of transfer to the denaturant solutions. In addition, the values of the favorable free energy obtained in this study are much smaller than the values obtained from the study of the amino acids. The transfer of the glycyl group to the denaturant solutions is exothermic whereas the transfer of the side chains is endothermic in nature.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-2960
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6661-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Effects of urea and guanidine hydrochloride on peptide and nonpolar groups.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't