Linked Life Data

6528079

Source:http://linkedlifedata.com/resource/pubmed/id/6528079

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-4-2
pubmed:abstractText
Systemic injections of kainic acid (KA) in adult rats rapidly induce sustained motor seizures preferentially involving the limbic structures and culminating in status epilepticus. The hippocampal formation and amygdala seem to occupy a central position for the onset of paroxysmal discharge and for the manifestation of limbic signs respectively. With long survival periods, the animals spontaneously display limbic motor seizures and a second administration of KA produces more severe effects. The brain damage, found in several limbic structures subsequent to KA-induced seizures, is reminiscent of that seen in human epileptics, and electrographical and metabolic studies (using the 2-deoxyglucose method) reveal that it follows increased neuronal and metabolic activation. The crucial role of the mossy fiber system in the particular vulnerability to KA of the CA3 neurons of Ammon's horn is also suggested by a study of the maturation of the KA-induced seizure and brain damage syndrome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0370-4475
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
241-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Usefulness of parenteral kainic acid as a model of temporal lobe epilepsy.
pubmed:publicationType
Journal Article