Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
15
|
| pubmed:dateCreated |
1985-3-14
|
| pubmed:abstractText |
Several X-ray structures of model crystals that contain hydroxyl group and nucleic-acid bases suggest that hydroxyl group interacts preferentially with pyrimidines than with purines through hydrogen bonds. This explains a role of Thr 45 and Ser 123 at the B1 site of RNAase A. The stacking energies of nucleic-acid bases with the protonated imidazolyl group are estimated to be in the order of C greater than A greater than G greater than U from 1H-NMR spectra and CNDO/2 calculations. Such interactions, in addition to hydrogen bondings, would stabilize the binding of substrates at the B2 site.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0261-3166
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
113-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6522281-Amino Acids,
pubmed-meshheading:6522281-Hydrogen Bonding,
pubmed-meshheading:6522281-Hydroxylation,
pubmed-meshheading:6522281-Models, Molecular,
pubmed-meshheading:6522281-Molecular Conformation,
pubmed-meshheading:6522281-Nucleic Acid Conformation,
pubmed-meshheading:6522281-Protein Conformation,
pubmed-meshheading:6522281-Purines,
pubmed-meshheading:6522281-Pyrimidines,
pubmed-meshheading:6522281-Ribonuclease, Pancreatic,
pubmed-meshheading:6522281-Structure-Activity Relationship,
pubmed-meshheading:6522281-Thermodynamics,
pubmed-meshheading:6522281-X-Ray Diffraction
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
A role of elementary interactions between nucleic-acid base and amino-acid side chains in specificity of ribonuclease.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|