Linked Life Data

6520061

Source:http://linkedlifedata.com/resource/pubmed/id/6520061

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-2-26
pubmed:abstractText
The in-vitro inactivation of seven antimicrobial drugs by human faecal substance has been investigated. Nalidixic acid, colistin, neomycin, tobramycin, temocillin, trimethoprim, and aztreonam were separately mixed in graded concentrations with faecal suspensions prepared from faeces of eight healthy volunteers. Each was mixed separately with a sample of each of the eight suspensions. All seven antimicrobial drugs appeared to be rapidly biologically inactivated by intestinal contents in a dose-dependent fashion, although not all to the same extent. The results may explain why with some unabsorbed or minimally absorbed drugs higher oral doses are required to achieve eradication of Gram-negative bacilli from the digestive tract than others, when selective decontamination (SD) is attempted in clinical practice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
605-12
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Biological inactivation by faeces of antimicrobial drugs applicable in selective decontamination of the digestive tract.
pubmed:publicationType
Journal Article