Linked Life Data

6517852

Source:http://linkedlifedata.com/resource/pubmed/id/6517852

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9-10
pubmed:dateCreated
1985-2-5
pubmed:abstractText
Frequency distributions of various plasminogen phenotypes in Japanese and American white populations were studied using electrofocusing in polyacrylamide gels followed by zymography and immunofixation. Using a synthetic substrate, tosyl-lysine-alpha-naphthyl ester, for zymography allowed zymography and immunofixation to be performed sequentially on the same gel plate. By this method, a nonfunctional abnormal plasminogen variant, plasminogen Tochigi, was readily detected in both plasma and serum. The gene frequency of this abnormal variant in a Japanese population was 0.018, whereas the abnormal variant was not detected in an American white population, suggesting the very rare occurrence of this variant in whites. Two common alleles, A and B, clearly identified in neuraminidase-treated samples, were observed at gene frequencies of 0.98 and 0.003, respectively, in the Japanese. These values are significantly different from the reported values in whites of 0.69 for A and 0.3 for B.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-2928
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
871-81
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Differences of frequency distributions of plasminogen phenotypes between Japanese and American populations: new methods for the detection of plasminogen variants.
pubmed:publicationType
Journal Article