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pubmed-article:6505692pubmed:abstractTextA monoclonal anti-idiotope antibody coupled to a carrier protein was used to immunize BALB/c mice against a lethal Streptococcus pneumoniae infection. Vaccinated mice developed a high titer of antibody to phosphorylcholine, which is known to protect against infection with Streptococcus pneumoniae. Measurement of the median lethal dose of the bacteria indicated that anti-idiotope immunization significantly increased the resistance of BALB/c mice to the bacterial challenge. Antibody to an idiotope can thus be used as an antigen substitute for the induction of protective immunity.lld:pubmed
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pubmed-article:6505692pubmed:articleTitleMonoclonal idiotope vaccine against Streptococcus pneumoniae infection.lld:pubmed
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