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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4680
|
pubmed:dateCreated |
1985-1-14
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pubmed:abstractText |
A monoclonal anti-idiotope antibody coupled to a carrier protein was used to immunize BALB/c mice against a lethal Streptococcus pneumoniae infection. Vaccinated mice developed a high titer of antibody to phosphorylcholine, which is known to protect against infection with Streptococcus pneumoniae. Measurement of the median lethal dose of the bacteria indicated that anti-idiotope immunization significantly increased the resistance of BALB/c mice to the bacterial challenge. Antibody to an idiotope can thus be used as an antigen substitute for the induction of protective immunity.
|
pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
pubmed:issn |
0036-8075
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
14
|
pubmed:volume |
226
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1325-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6505692-Animals,
pubmed-meshheading:6505692-Antibodies, Monoclonal,
pubmed-meshheading:6505692-Bacterial Vaccines,
pubmed-meshheading:6505692-Immunoglobulin Idiotypes,
pubmed-meshheading:6505692-Mice,
pubmed-meshheading:6505692-Mice, Inbred BALB C,
pubmed-meshheading:6505692-Phosphorylcholine,
pubmed-meshheading:6505692-Pneumococcal Infections,
pubmed-meshheading:6505692-Streptococcus pneumoniae,
pubmed-meshheading:6505692-Vaccination
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pubmed:year |
1984
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pubmed:articleTitle |
Monoclonal idiotope vaccine against Streptococcus pneumoniae infection.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|