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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1985-1-15
|
pubmed:abstractText |
Survival and G2 delay of L929 mouse fibroblasts exposed to 3.4-MeV alpha particles depend on the cell age at the time of irradiation. Greatest sensitivity for both endpoints has been found at the G1/S transition: The surviving fraction of G1/S cells is reduced to 0.11 following 1 Gy of alpha particles compared to 0.31 for early G1 cells. The G2 + M transit time rises from 3 hr for control cells to 22 and 30 hr for cells irradiated with 0.3 Gy in G2 or at the G1/S boundary, respectively. Cells irradiated in early G1 do not show increased G2 + M transit times. Growth delay as calculated for the entire population increases linearly with dose by 23 hr/Gy of alpha particles.
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pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0033-7587
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
100
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
576-84
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6505145-Alpha Particles,
pubmed-meshheading:6505145-Americium,
pubmed-meshheading:6505145-Animals,
pubmed-meshheading:6505145-Cell Survival,
pubmed-meshheading:6505145-Interphase,
pubmed-meshheading:6505145-L Cells (Cell Line),
pubmed-meshheading:6505145-Mice,
pubmed-meshheading:6505145-Time Factors
|
pubmed:year |
1984
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pubmed:articleTitle |
Cell cycle dependent G2 delay and killing of L929 cells after exposure to 241Am alpha particles.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|