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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1985-1-18
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pubmed:abstractText |
A nerve-conditioning lesion induced sustained acceleration of limb regeneration. Newt limb nerves were subjected to a conditioning lesion by unilateral axotomy at the elbow 2 weeks prior to amputating both limbs above the elbows. Limbs on the side that had received a conditioning lesion began the regeneration process 3-4 days earlier than contralateral controls and this difference was observed up to recognizable digit formation. Limb buds on the conditioned sides had a twofold greater axonal density than contralateral counterparts at 2 weeks after amputation. Since limb bud formation is dependent on a sufficient quantity of axonal regrowth, accelerated limb regeneration is apparently due to accelerated reinnervation.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-104X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
232
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
181-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6502096-Amputation,
pubmed-meshheading:6502096-Animals,
pubmed-meshheading:6502096-Axons,
pubmed-meshheading:6502096-Brachial Plexus,
pubmed-meshheading:6502096-Forelimb,
pubmed-meshheading:6502096-Nerve Crush,
pubmed-meshheading:6502096-Nerve Regeneration,
pubmed-meshheading:6502096-Notophthalmus viridescens,
pubmed-meshheading:6502096-Regeneration,
pubmed-meshheading:6502096-Salamandridae
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pubmed:year |
1984
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pubmed:articleTitle |
A nerve-conditioning lesion accelerates limb regeneration in the newt.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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