|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
1977-3-31
|
|
pubmed:abstractText |
Mouse alpha-fetoprotein (AFP) suppressed the specific antibody response to the T-cell-dependent antigen sheep erythrocytes (SRBC) and the phytohemagglutinin- and concanavalin-A-stimulated DNA synthesis of purified T lymphocytes but failed to inhibit the T-cell-independent antibody response to dinitrophenyl-substituted Ficoll (DNP-Ficoll) and the lipopolysaccharide-stimulated polyclonal B-cell antibody synthesis. Mouse amniotic fluid (MAF) suppressed antibody responses to both T-cell-dependent and T-cell-independent antigens; however, the effects could be differentiated since dialysis of the MAF removed most of the suppressive effect on the DNP-Ficoll response but did not diminish the inhibitory action on the anti-SRBC response. The results indicate that AFP suppresses certain T-lymphocyte functions in vitro and does not act by directly inhibiting B-cell functions.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0300-9475
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1215-20
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:65007-Amniotic Fluid,
pubmed-meshheading:65007-Animals,
pubmed-meshheading:65007-Antibody Formation,
pubmed-meshheading:65007-B-Lymphocytes,
pubmed-meshheading:65007-Concanavalin A,
pubmed-meshheading:65007-DNA,
pubmed-meshheading:65007-Female,
pubmed-meshheading:65007-Ficoll,
pubmed-meshheading:65007-Lectins,
pubmed-meshheading:65007-Lipopolysaccharides,
pubmed-meshheading:65007-Lymphocyte Activation,
pubmed-meshheading:65007-Lymphocytes,
pubmed-meshheading:65007-Mice,
pubmed-meshheading:65007-Mice, Inbred C57BL,
pubmed-meshheading:65007-Mice, Inbred CBA,
pubmed-meshheading:65007-Pregnancy,
pubmed-meshheading:65007-T-Lymphocytes,
pubmed-meshheading:65007-alpha-Fetoproteins
|
|
pubmed:year |
1976
|
|
pubmed:articleTitle |
The effects of mouse alpha-fetoprotein on T-cell-dependent and T-cell-independent immune responses in vitro.
|
|
pubmed:publicationType |
Journal Article
|
