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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3-4
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pubmed:dateCreated |
1984-12-28
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pubmed:abstractText |
The effect of ketanserin on the action of 5-hydroxytryptamine (5-HT) and noradrenaline has been studied using the rat isolated perfused mesentery preparation. Both 5-HT and noradrenaline produced constriction in the mesenteric vessels. The responses to 5-HT and noradrenaline were greater in tissues from hypertensive animals. Responses to 5-HT were abolished by 1 nM ketanserin. Ketanserin was found to be a competitive antagonist of the noradrenaline-induced constrictions (pA2 = 7.5). In partially constricted tissues, 5-HT induced vasoconstriction and vasodilation. In the presence of ketanserin the vasoconstriction was reduced and the 5-HT-induced vasodilation was potentiated. The amount of potentiation of the 5-HT-induced vasodilation by ketanserin was similar in tissues from normotensive and hypertensive rats. It is suggested that the 5-HT-induced vasoconstriction is mediated by activation of 5-HT2 receptors. In the presence of ketanserin, the 5-HT2 receptor mediated vasoconstriction is antagonized, unmasking a 5-HT-induced vasodilation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
313-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6499925-Amidines,
pubmed-meshheading:6499925-Animals,
pubmed-meshheading:6499925-Antihypertensive Agents,
pubmed-meshheading:6499925-Blood Pressure,
pubmed-meshheading:6499925-Hypertension,
pubmed-meshheading:6499925-Ketanserin,
pubmed-meshheading:6499925-Male,
pubmed-meshheading:6499925-Norepinephrine,
pubmed-meshheading:6499925-Piperidines,
pubmed-meshheading:6499925-Rats,
pubmed-meshheading:6499925-Serotonin,
pubmed-meshheading:6499925-Serotonin Antagonists,
pubmed-meshheading:6499925-Vasoconstriction,
pubmed-meshheading:6499925-Vasodilation
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pubmed:year |
1984
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pubmed:articleTitle |
Antagonism by ketanserin of 5-HT-induced vasoconstriction unmasks a 5-HT-induced vasodilation.
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pubmed:publicationType |
Journal Article,
In Vitro
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