Linked Life Data

6498483

Source:http://linkedlifedata.com/resource/pubmed/id/6498483

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-12-28
pubmed:abstractText
There are marked regional variations in the laminar distribution and intensity of acetylcholinesterase containing fibers in cortex. These fibers were particularly prominent in the 5 major paralimbic (mesocortical) regions of the brain: the insula, the caudal orbito-frontal cortex, the temporal pole, the cingulate gyrus and the parahippocampal region. Within these 5 areas, the part of cortex which is adjacent to allocortex has the most acetylcholinesterase and there is a gradual decline towards granular isocortex. The primary sensory-motor areas have distinctive laminar patterns of enzyme distribution. For example, primary visual, auditory and somesthetic konio-cortices are characterized by a salient band in layer IV. On the other hand, motor and premotor areas are characterized by a concentration of radially arranged fibers within the deeper layers of cortex. High order sensory association areas throughout the cortical mantle consistently contain the least amount of acetylcholinesterase-positive fibers. It is conceivable that these patterns reflect regional variations in the distribution of cortical cholinergic innervation. The cortical topography of cholinergic markers may be relevant to the biological organization of mood and memory and also to the pathophysiology of Alzheimer's disease and of partial epilepsy.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
311
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-58
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Regional variations in cortical cholinergic innervation: chemoarchitectonics of acetylcholinesterase-containing fibers in the macaque brain.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't