Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-12-7
pubmed:abstractText
The effect of mast-cell-triggering peptides on the rotational properties of band 3, a protein component of the human erythrocyte membrane, was measured by observing flash-induced transient dichroism of the triplet probe eosin maleimide. In the presence of melittin, polylysine and five synthetic peptides, varying degrees of retardation in the rotational motion of band 3 were produced. When placed in order of band 3 immobilizing activity, the peptides formed a series identical with their order of efficacy in releasing 5-hydroxytryptamine from rat peritoneal mast cells. The correspondence in the abilities to immobilize band 3 in the erythrocyte and trigger mast cells is significant because structure-activity analyses of the peptides show both processes to have the same cationic, hydrophobic and stereochemical requirements. Probably, the immobilization of band 3 proteins reflects an ability of the basic peptides to aggregate anionic surface moieties, and therefore a similar mechanism is implied in mast-cell triggering.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-224909, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-2324, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-391281, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-4113805, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-4121082, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-4125520, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-4326772, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-6158341, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-6161147, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-6345535, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-6425646, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-6871201, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-6933517, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-7173980, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-723269, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-7275186, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-7326027, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-7378378, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-90504, http://linkedlifedata.com/resource/pubmed/commentcorrection/6497847-92986
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
223
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-71
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
The capacity of basic peptides to trigger exocytosis from mast cells correlates with their capacity to immobilize band 3 proteins in erythrocyte membranes.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't