Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1984-12-19
|
pubmed:abstractText |
High lumbar epidural block was induced in seven dogs with 0.5% bupivacaine, causing a fall in mean arterial blood pressure (AP) from 19.2 +/- 3.2 to 10.5 +/- 3.2 kPa, owing to equal reductions in cardiac output (QT) and systemic vascular resistance (SVR). After the administration of ephedrine (a single injection of 200-300 micrograms X kg-1 b.w. followed by a continuous infusion of 10-20 micrograms X kg-1 b.w. X min-1) AP, QT and SVR rose to pre-epidural values. Furthermore, the hypokinetic circulation following the epidural block returned to normokinetic levels. Portal venous blood flow was increased from 16.5 +/- 6.2 to 25.5 +/- 4.3 ml X kg-1 b.w. X min-1 by ephedrine, while the hepatic arterial blood flow was unchanged and remained at its pre-epidural level. In spite of a slight rise in hepatic oxygen consumption from 1.2 +/- 0.4 to 1.6 +/- 0.6 ml X kg-1 b.w. X min-1, the percentages of oxygen extracted from the portal vein and the hepatic artery decreased significantly. It is concluded that ephedrine restores central and splanchnic haemodynamics in a desirable manner during high epidural anaesthesia.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0001-5172
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
28
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
557-62
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:6496016-Anesthesia, Epidural,
pubmed-meshheading:6496016-Animals,
pubmed-meshheading:6496016-Blood Pressure,
pubmed-meshheading:6496016-Bupivacaine,
pubmed-meshheading:6496016-Cardiac Output,
pubmed-meshheading:6496016-Dogs,
pubmed-meshheading:6496016-Ephedrine,
pubmed-meshheading:6496016-Female,
pubmed-meshheading:6496016-Hemodynamics,
pubmed-meshheading:6496016-Liver,
pubmed-meshheading:6496016-Liver Circulation,
pubmed-meshheading:6496016-Male,
pubmed-meshheading:6496016-Oxygen Consumption,
pubmed-meshheading:6496016-Portal System,
pubmed-meshheading:6496016-Splanchnic Circulation,
pubmed-meshheading:6496016-Vascular Resistance
|
pubmed:year |
1984
|
pubmed:articleTitle |
Effects of ephedrine on haemodynamics and oxygen consumption in the dog during high epidural block with special reference to the splanchnic region.
|
pubmed:publicationType |
Journal Article
|