Linked Life Data

6493627

Source:http://linkedlifedata.com/resource/pubmed/id/6493627

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
1984-12-20
pubmed:abstractText
Differential pulse voltammetry associated with carbon fiber microelectrodes was used to detect the 300 mV signal which is known to reflect the concentration of 5-hydroxyindoles in the spinal cord and cerebral neocortex of rats anesthetized with urethane or chloral hydrate. The intraperitoneal injection of p-chloroamphetamine resulted in an increase in the amplitude of the signal in the neocortex but not in the spinal cord. Administration of clorgyline did not consistently modify the signal monitored in the neocortex whereas it decreased in the spinal cord. Probenecid induced a larger increase in 5-hydroxyindoles in the neocortex than in the spinal cord. These results demonstrate that different parts of the serotonergic system might be differentially sensitive to drugs affecting serotonin metabolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
231-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
In vivo electrochemical detection of 5-hydroxyindoles in rat cerebral cortex and spinal cord: differential effects of p-chloroamphetamine, probenecid and clorgyline.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't