Linked Life Data

649063

Source:http://linkedlifedata.com/resource/pubmed/id/649063

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1978-7-15
pubmed:abstractText
An extract of rat liver, made 12 h after partial hepatectomy, was injected into untreated rats. The synthesis of DNA in the liver cells of the injected animals showed a 3.3 fold increase in comparison with controls. A similar increase was observed in the mitosis index. Injection of liver extracts from normal rats showed no effect when compared with the injection of NaCl. The effect of the active extract was not altered by neuraminidase treatment. Trypsin-chymotrypsin treatment, howerver, removes the activity. The active factor must therefore be either a protein or a protein-like substance. The molecular weight of the factor was shown to be between about 30 000 and 50 000 by molecular filtration. The specific activity after molecular filtration was raised by a factor of 100. The factor is inert with respect to the proliferation of kidney and spleen. It is apparently not species-specific, however, since it also causes increased proliferation of liver cells in normal mice.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0018-4888
pubmed:author
pubmed:issnType
Print
pubmed:volume
359
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
543-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
[Concentration and characterization of a liver cell proliferation factor from partially hepatectomized rat livers (author's transl)].
pubmed:publicationType
Journal Article, English Abstract