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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1984-12-20
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pubmed:abstractText |
The relative bioavailability of lymecycline and tetracycline hydrochloride was compared in 12 healthy volunteers in a double-blind cross-over study using a high performance liquid chromatographic method for plasma and urine analyses. A statistical significant difference in favour of tetracycline hydrochloride was found concerning the mean AUC and the mean lag time. The relative bioavailability of lymecycline was only 70% compared with tetracycline in multiple dosing (19.13 +/- 5.39 micrograms ml-1 h and 27.22 +/- 6.26 micrograms ml-1 h respectively) and 80% in a single dose (21.88 +/- 4.23 micrograms ml-1 h and 26.91 +/- 6.01 respectively) and the mean lag time of tetracycline was only 60% compared with lymecycline.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6487493-4278440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6487493-4587517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6487493-4751594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6487493-4981622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6487493-5008196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6487493-557329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6487493-5818724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6487493-671223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6487493-6756937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6487493-7062250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6487493-7079759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6487493-7153285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6487493-750180
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
529-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1984
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pubmed:articleTitle |
Comparative bioavailability of tetracycline and lymecycline.
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pubmed:publicationType |
Journal Article,
Comparative Study
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