rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1984-11-19
|
pubmed:abstractText |
The cholesterol and phospholipid content of microsomal membrane from rats fed either a high lipid (H1) (30% lard) or a low protein (Lp) diet (6% casein) have been compared with those from rats fed a standard (St) diet (22% casein, 5% lard). For each diet, half of the group was treated with Phenochlor DP6. A significant increase in the phospholipid cholesterol ratio was observed in rats fed a high lipid diet or treated with DP6. These effects tend to increase the microsomal membrane fluidity. The protein deficiency decreased the phospholipid/cholesterol ratio and then the fluidity of the endoplasmic reticulum membrane. The specific activity of cytochrome P-450 to hydroxylate aniline which is independent to the enzymic form of cytochrome P-450 was closely correlated with the viscosity status of the microsomal membrane.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0378-4274
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
23
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
73-7
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6485021-Aniline Hydroxylase,
pubmed-meshheading:6485021-Animals,
pubmed-meshheading:6485021-Cholesterol,
pubmed-meshheading:6485021-Cytochrome P-450 Enzyme System,
pubmed-meshheading:6485021-Dietary Fats,
pubmed-meshheading:6485021-Lipid Metabolism,
pubmed-meshheading:6485021-Male,
pubmed-meshheading:6485021-Membrane Fluidity,
pubmed-meshheading:6485021-Membrane Lipids,
pubmed-meshheading:6485021-Microsomes, Liver,
pubmed-meshheading:6485021-Oxygenases,
pubmed-meshheading:6485021-Phospholipids,
pubmed-meshheading:6485021-Rats,
pubmed-meshheading:6485021-Rats, Inbred Strains
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pubmed:year |
1984
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pubmed:articleTitle |
Lipid composition and monooxygenase relationship in liver microsomal membranes from rats fed unbalanced diets.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|