Linked Life Data

6484496

Source:http://linkedlifedata.com/resource/pubmed/id/6484496

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 2
pubmed:dateCreated
1984-11-20
pubmed:abstractText
Neutrophil granulocytes migrate rapidly into three-dimensional gels of native collagen fibres, the leading front of the cell population moving approximately 100 micron/hour when the cells are unstimulated. Migration occurs in the apparent absence of adhesion to collagen fibres, as neutrophils do not adhere to collagen-coated glass and are unable to locomote over collagen-coated surfaces, probably due to lack of traction with the substratum. It would appear, therefore, that the mechanism of neutrophil movement through three-dimensional collagen gels is fundamentally different to the mechanism of migration over a planar substratum. Freshly isolated blood monocytes do not invade collagen gels. However, if monocytes are cultured on serum-coated plastic, approximately 80% of the cells spontaneously detach from the culture surface over a 48 hour period: these detached cells invade collagen gels, although at a much slower rate than neutrophils.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0586-5581
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
747-54
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Neutrophil and monocyte behaviour in three-dimensional collagen matrices.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't