Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1984-11-1
|
pubmed:abstractText |
Rats pretreated for 5 days with 50 mg/kg of pentobarbital tolerated statistically significant higher doses of misonidazole before the onset of misonidazole-induced neurotoxicity than rats treated intermittently with the same dose of pentobarbital. Presumably in pretreated rats, pentobarbital induced an increase in the activities of hepatic microsomal enzymes that led to a more rapid metabolism of misonidazole than in rats treated only intermittently.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0167-594X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
2
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
95-8
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:6481429-Animals,
pubmed-meshheading:6481429-Enzyme Induction,
pubmed-meshheading:6481429-Male,
pubmed-meshheading:6481429-Microsomes, Liver,
pubmed-meshheading:6481429-Misonidazole,
pubmed-meshheading:6481429-Nitroimidazoles,
pubmed-meshheading:6481429-Pentobarbital,
pubmed-meshheading:6481429-Rats,
pubmed-meshheading:6481429-Rats, Inbred Strains
|
pubmed:year |
1984
|
pubmed:articleTitle |
Misonidazole neurotoxicity in rats: Part II. Effect of pre- and intermittent treatment with pentobarbital on misonidazole neurotoxicity in the rat.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|