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This is a clinicopathologic study of six patients with mucinous syringometaplasia, which was diagnosed histologically. Biopsies revealed a focal invagination of the epidermis lined by squamous epithelium, with one or several eccrine ducts leading into the vagination. The eccrine duct epithelium contained mucin-laden goblet cells, and there was mucinous syringometaplasia of the underlying eccrine coils. This histopathologic change was associated with two types of clinical lesions: (1) verrucous lesions, consistent with those described by previous authors, and (2) lesions suggestive of basal cell carcinoma, which have not been described with this pathologic entity in previous publications.
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