Linked Life Data

6478800

Source:http://linkedlifedata.com/resource/pubmed/id/6478800

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-11-6
pubmed:abstractText
Samples of rat plasma, in which activity of lecithin-cholesterol acyltransferase was inhibited, were incubated in vitro at 37 degrees C for 6 hr in the presence and absence of a partially purified preparation of human lipid transfer protein (LTP). After the incubation gel filtration chromatography was used to separate plasma lipoproteins into multiple fractions which were individually assayed to obtain a complete profile of all constituents across the whole lipoprotein spectrum. When plasma from both normal and cholesterol-fed rats was incubated in the absence of LTP there were no changes in the distribution of any of the lipoprotein constituents between different fractions. When, however, normal plasma was incubated in the presence of LTP there was an obvious transfer of cholesteryl esters from high density lipoproteins (HDL) to very low density lipoproteins (VLDL) and of triglyceride from VLDL to HDL. The presence of LTP in incubations of plasma from cholesterol-fed rats, by contrast, resulted in only minimal redistributions of constituents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0305-0491
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
675-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Incubation of human lipid transfer protein with plasma from normal-fed and cholesterol-fed rats: effect on the distribution of constituents between lipoprotein fractions.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't