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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1984-11-2
|
| pubmed:abstractText |
The metabolism of the new reversible A-selective monoamine oxidase inhibitor amiflamine was studied in relation to polymorphic hydroxylation of debrisoquine in 24 healthy subjects. Amiflamine is metabolized by two consecutive N-demethylations. By construction of urinary recovery ratios analogous to that of debrisoquine/4-hydroxydebrisoquine, correlations between debrisoquine metabolic ratio and amiflamine/demethylated metabolites were significant and consistent within slow and rapid hydroxylators of debrisoquine. It is concluded that debrisoquine hydroxylation and amiflamine N-demethylation might be under common genetic regulation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0009-9236
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
515-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6478737-Administration, Oral,
pubmed-meshheading:6478737-Adult,
pubmed-meshheading:6478737-Biotransformation,
pubmed-meshheading:6478737-Debrisoquin,
pubmed-meshheading:6478737-Humans,
pubmed-meshheading:6478737-Hydroxylation,
pubmed-meshheading:6478737-Isoquinolines,
pubmed-meshheading:6478737-Male,
pubmed-meshheading:6478737-Phenethylamines,
pubmed-meshheading:6478737-Polymorphism, Genetic
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Relationship of N-demethylation of amiflamine and its metabolite to debrisoquine hydroxylation polymorphism.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|