Linked Life Data

6477201

Source:http://linkedlifedata.com/resource/pubmed/id/6477201

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-10-19
pubmed:abstractText
A sheep model is described that reliably produces acute pulmonary hypertension after blood, previously in contact with a number of different dialysis membranes including Cuprophan, enters the animal's circulation. This hemodynamic manifestation is associated with myocardial ischemia and arrhythmias and coincides in time with neutropenia but precedes maximal hypoxemia. The resulting pulmonary vascular response occurs following both exposure of flowing blood to a dialyzer in an extracorporeal circuit and reinjection of blood previously in static contact with a number of different devices for varying periods of time. Increasing volumes (1-15 ml) previously in static contact (10 min) with regenerated cellulose, saponified cellulose ester, and Cuprophan (hollow fiber and sheet form) caused varying increments in mean pulmonary artery pressure. Contact with either polyacrylonitrile or cellulose acetate resulted in little response. This effect was magnified with all the surfaces, even polyacrylonitrile and cellulose acetate, by prolonging the duration of contact up to 30 min. The hemodynamic events that occurred with this model are similar to those reported in the clinical entity of "dialyzer hypersensitivity." This model may be of value in the quest for elucidation of the mechanisms involved in this syndrome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0160-564X
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
329-33
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Blood--dialyzer interactions: hemodynamic manifestations in an animal model.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't