Linked Life Data

6470966

Source:http://linkedlifedata.com/resource/pubmed/id/6470966

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1984-10-12
pubmed:abstractText
Polyalkyl cyanoacrylate nanoparticles were previously developed as a biodegradable, ultrafine, solid drug carrier. Distribution studies in the rat showed an intense and rapid hepatic uptake. This liver accumulation appears to represent, to a certain extent, extracellularly bound nanoparticles. During liver perfusion, 15-20% of the liver-associated nanoparticles were washed out. The cellular distribution of strongly cell-associated nanoparticles was determined. At different intervals after injection of radioactive nanoparticles to rats, the cells were isolated according to a recently developed, low-temperature procedure during which processing of the carrier was inhibited. At all tested times, a relatively intense capture by Kupffer cells in comparison with endothelial and especially parenchymal cells was observed. This distribution pattern was not influenced by the size of the nanoparticles (0.08-0.215-micron diameter). This specific interaction of nanoparticles with Kupffer cells opens possibilities for the treatment of some parasitic diseases involving this cell type.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-3549
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
980-2
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
In vivo uptake of polyisobutyl cyanoacrylate nanoparticles by rat liver Kupffer, endothelial, and parenchymal cells.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't