Linked Life Data

6470137

Source:http://linkedlifedata.com/resource/pubmed/id/6470137

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-10-24
pubmed:abstractText
The humoral hypercalcemia of malignancy (HHM) is caused by tumor cells that release a circulating factor which stimulates osteoclastic bone resorption. Recently, it has been reported that tumors associated with HHM contain factors that stimulate renal and bone cell adenylate cyclase. The activity was inhibited by parathyroid hormone (PTH) antagonists, and this led to the hypothesis that hypercalcemia is due to bone resorbing factors that engage PTH receptors in bone. Since it is not known whether the bone resorbing factors act via PTH receptors in bone, we examined the effects of PTH antagonists on PTH-stimulated bone resorption and bone resorbing activity that was produced by two tumor models of HHM which also release these adenylate cyclase stimulating factors. The PTH antagonists [8,18norleucine, 34tyrosine]bovine PTH (3-34) amide and [34tyrosine]bovine PTH (7-34) completely inhibited PTH-stimulated bone resorption. Neither antagonist inhibited bone resorption that was stimulated by the conditioned medium from cells that were derived from the Walker rat 256 tumor model of HHM. Both antagonists also failed to inhibit bone resorption that was stimulated by culture media from cells that were derived from the rat Leydig cell tumor. These data suggest that in these two models of HHM, the bone resorbing factors do not exert their effects by interacting with PTH receptors on bone.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6470137-1173020, http://linkedlifedata.com/resource/pubmed/commentcorrection/6470137-14254246, http://linkedlifedata.com/resource/pubmed/commentcorrection/6470137-6253785, http://linkedlifedata.com/resource/pubmed/commentcorrection/6470137-6298282, http://linkedlifedata.com/resource/pubmed/commentcorrection/6470137-6298791, http://linkedlifedata.com/resource/pubmed/commentcorrection/6470137-6301659, http://linkedlifedata.com/resource/pubmed/commentcorrection/6470137-6302844, http://linkedlifedata.com/resource/pubmed/commentcorrection/6470137-6577602, http://linkedlifedata.com/resource/pubmed/commentcorrection/6470137-6685137, http://linkedlifedata.com/resource/pubmed/commentcorrection/6470137-6849118, http://linkedlifedata.com/resource/pubmed/commentcorrection/6470137-6871760
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1104-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Failure of parathyroid hormone antagonists to inhibit in vitro bone resorbing activity produced by two animal models of the humoral hypercalcemia of malignancy.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't