Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1984-10-22
pubmed:abstractText
In a series of 59 experiments in nine duodenal ulcer patients, 24 hour intragastric acidity was measured before, during, and after treatment with daily oral omeprazole. Omeprazole 10, 20, and 30 mg/day for one week caused a 37, 90, and 97% decrease of 24 hour intragastric acidity, respectively. No further decrease of acidity was observed when the dose of omeprazole was doubled to 60 mg/day, or after a second week of treatment with 30 mg/day. One week after stopping treatment with omeprazole (14 doses) there was a significant 26% decrease of 24 hour intragastric acidity, with full recovery seven weeks later. Fasting plasma gastrin concentration was significantly raised during treatment with all doses of omeprazole. Omeprazole 30 mg/day is the optimal dose for a maximal decrease of 24 hour intragastric acidity in duodenal ulcer patients.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-12175, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-159310, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-323118, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-4361, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-456231, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-53554, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-6109686, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-6129180, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-6134979, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-6135864, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-6282679, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-6291138, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-6293317, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-6299338, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-6303891, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-6303916, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-6359, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-6407676, http://linkedlifedata.com/resource/pubmed/commentcorrection/6469081-6832622
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0017-5749
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
957-64
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity.
pubmed:publicationType
Journal Article