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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1984-10-19
|
| pubmed:abstractText |
The pharmacokinetics of cefoperazone after i.p. and/or i.v. administration were studied in 12 CAPD patients. After i.v. injection, the plasma half-life was 2.65 +/- 0.4 h, the total clearance amounting to 70.1 +/- 19.2 ml/min. Peritoneal clearance was calculated to be 6.9 +/- 1 ml/min. After peritoneal instillation, the bioavailability was 63.9 +/- 5%. After repeated i.p. administration, no accumulation of the drug in the body was observed. Thus, cefoperazone can be safely administered for the treatment of peritonitis in CAPD patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0031-6970
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
609-12
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:6468477-Cefoperazone,
pubmed-meshheading:6468477-Humans,
pubmed-meshheading:6468477-Kinetics,
pubmed-meshheading:6468477-Liver,
pubmed-meshheading:6468477-Metabolic Clearance Rate,
pubmed-meshheading:6468477-Peritoneal Dialysis,
pubmed-meshheading:6468477-Peritoneal Dialysis, Continuous Ambulatory
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Pharmacokinetics of cefoperazone in patients undergoing chronic ambulatory peritoneal dialysis: clinical and pathophysiological implications.
|
| pubmed:publicationType |
Journal Article
|