Linked Life Data

6468463

Source:http://linkedlifedata.com/resource/pubmed/id/6468463

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1984-10-22
pubmed:abstractText
We describe the application of a simple and reliable experimental model for studying intestinal permeability. Swedish Landrace pigs were anesthetized and catheters put in the carotid artery, the external jugular vein, the proximal part of the duodenum, and the urinary bladder. A mixture of polyethylene glycols (PEGs) with molecular weights ranging from 414 to 1,074 daltons was then instilled into the duodenum and the urinary recovery of different-sized PEGs determined at time intervals using reversed-phase high-performance liquid chromatography. The recovery was inversely related to molecular size; after 4 h, 13.7% of the instilled amount of PEG 414 was recovered in the urine, whereas the corresponding value for PEG 1,074 was 0.34%. The presence of bile in the duodenum increased the recoveries of all PEGs: corresponding values for PEG 414 and 1,074 were then 28.3 and 0.79%, respectively. These data indicate that (i) intestinal permeability to PEGs in the 414- to 1,074-dalton range can be studied in a quantitative, yet simple way using a pig experimental model, and (ii) the presence of bile in the duodenum considerably increases the intestinal absorption of 414- to 1,074-dalton PEGs. The possibility that bile interacts with PEGs much the same as with hydrophobic and amphiphilic compounds is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0014-312X
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
274-81
pubmed:dateRevised
2006-11-30
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Passage of molecules through the wall of the gastrointestinal tract. Intestinal permeability to polyethylene glycols in the 414- to 1,074-dalton range.
pubmed:publicationType
Journal Article